129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments
نویسندگان
چکیده
منابع مشابه
129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments
Methods and results The present experiments firstly tested whether deficits in extinguishing emotional responses in S1 extends to contextual extinction. No reduction in emotional responses to the context was observed during an extinction training session which indicates generalised inability of S1 to engage associative fear extinction mechanisms. This was in contrast to mice of another 129 stra...
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BACKGROUND MicroRNA (miRNA)-mediated control of gene expression suggests that miRNAs are interesting targets and/or biomarkers in the treatment of anxiety- and trauma-related disorders, where often memory-associated gene expression is adversely affected. METHODS The role of miRNAs in the rescue of impaired fear extinction was assessed using the 129S1/SvlmJ (S1) mouse model of impaired fear ex...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2011
ISSN: 1471-2210
DOI: 10.1186/1471-2210-11-s2-a39